- Wed Dec 17 (room reservation 11:00 JST [=UTC+09:00]), ELSI-1 207 Seminar Room B [Seminar] Tentative for video shooting by Admin requested by University HQ(Center for Entrepreneurship Education) - Fri Dec 19 (room reservation 10:00 JST [=UTC+09:00]), ELSI-1 105 Mishima Hall [Seminar] ELSI Seminar - Dieter Braun Dieter Braun Ludwig-Maximilians-Universität München Title: Testing twelve Dogmas on the Origin of Life Abstract: The experimental lessons that we have learned in recent years are grouped along what I consider dogmas in the field of the origin of life. Overcoming these will allow for a simpler and more geologically compatible RNA world scenario. The dogmas are as follows: • Life emerged in the liquid state • Activation is at the 5’ end of RNA • Life emerged at pH 7 • RNA is unstable • Amino acids are missing an initial function • Only Ribozymes are catalytic • Molecules of Life are single sided • Only activated molecules drive the system • Early life required autotrophy and metabolism • Life needs cells • Evolution is growth • The Origin of Life is slow. I will contradict these dogmas by experimental counterexamples. These experiments led our group to a realistic and progressively tested hypothesis about how life emerged. In short, it can be summarized as follows: The accumulation of polymerising molecules is exponentially amplified by local flow. The polymerisation of 2',3'-cyclic nucleobases at a pH of 9–10, which is geologically realistic, forms replication networks by ligation. These networks grow and recycle in wet-dry cycles between day and night. RNA self-purifies into left- and right-handed homochiral strands; the right-handed strand is selected much later. Replication is much faster when RNA is pinned, fed, and selected for length and replication speed by thermal gradients. In such a setting, gas bubbles form cells for lateral gene transfer. These thermal settings continue to drive modern biochemistry, demonstrating a long-term habitat. Based on above experiments, life can emerge through molecular evolution under exponential accumulation in volcanic rock. That is does in lab experiments is task for the next few years. zoom link: https://us06web.zoom.us/j/6625820729?pwd=U3RNblNxVm9yTG8wL0ltRHdyaTQ5QT09 - Fri Dec 19 (room reservation 11:00 JST [=UTC+09:00]), ELSI-1 105 Mishima Hall [Seminar] Lecture_Dieter Braun *Students are higly encouraged to attend Lecturer Dr. Dieter Braun Ludwig-Maximilians-Universität München - Fri Dec 19 (room reservation 14:00 JST [=UTC+09:00]), ELSI-1 207 Seminar Room B [Study Group] Metabolism Hour - Fri Dec 19 (room reservation 15:00 JST [=UTC+09:00]), ELSI-1 207 Seminar Room B [Seminar] Protein language model hour Study group for protein language models